2-Methyl-4-methoxyaniline → N-(4-Methoxy-2-methylphenyl)-acetamide

HRID 634738

반응식

HRID 634738 반응식
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][O:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[C:12]([CH3:17])[CH:11]=1>CC(N(C)C)=O>[CH3:8][O:9][C:10]1[CH:16]=[CH:15][C:13]([NH:14][C:1](=[O:3])[CH3:2])=[C:12]([CH3:17])[CH:11]=1

참가 물질

4

반응물 2

HCID 76102-Methyl-4-methoxyanilineHCID 7918Acetic Anhydride

생성물 1

HCID 95082N-(4-Methoxy-2-methylphenyl)-acetamide수율 88%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

Acetic anhydride (50 ml) was added dropwise to a solution of 4-methoxy-2-methylaniline (49.7 g, 360mmol) in DMA (200 ml) at 5° C. and the mixture stirred for 4.5 hours at ambient temperature. The solvent was removed by evaporation and the resulting solid washed with water and dried under vacuum to give N-(4-methoxy-2-methylphenyl)acetamide (57.3 g, 88%).

후처리

  1. customThe solvent was removed by evaporation
  2. washthe resulting solid washed with water
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-176f1a6305aa4a55a6e8c9853f2cfc64
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184225B2

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