Hydrogen Bromide → 1-Ethyl-2,2,4-trimethyl-1,2-dihydroquinolin-7-ol

HRID 634910노트

반응식

HRID 634910 반응식
Br.[CH2:2]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[C:7]([CH3:15])=[CH:6][C:5]1([CH3:17])[CH3:16])[CH3:3].C([O-])(=O)C.[Na+].Br>O.C(Cl)(Cl)Cl>[CH2:2]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[C:7]([CH3:15])=[CH:6][C:5]1([CH3:16])[CH3:17])[CH3:3]

참가 물질

6

반응물 3

HCID 260Hydrogen BromideHCID 517045Sodium AcetateHCID 21260952N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide

생성물 1

HCID 154511031-Ethyl-2,2,4-trimethyl-1,2-dihydroquinolin-7-ol

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매

실험 절차

200 g N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide was suspended in a mixture of 1 l water and 500 ml chloroform. 20% sodium acetate solution was added to this suspension until the pH value reached ca. 5. The organic phase was washed with water, dried over sodium sulfate and evaporated to dryness in a rotary evaporator. A light-brown oil was obtained in this manner. Since the released base decomposes very rapidly, only the required amount of base for the further process was released from the hydrobromide.

후처리

  1. washThe organic phase was washed with water
  2. dry with materialdried over sodium sulfate
  3. customevaporated to dryness in a rotary evaporator
  4. customA light-brown oil was obtained in this manner

출처 및 근거

ORD 기록
ord-20f5b970b52d4e76a10484ba45fb3ed4
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184379B2

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