Hydrochloric Acid → HCID 178525233, 화합물

HRID 634959노트

반응식

HRID 634959 반응식
C([O:3][C:4]([CH2:6][C:7]1[N:8]=[C:9]([SH:12])[S:10][CH:11]=1)=[O:5])C.[OH-].[Na+].Cl>O>[C:4]([CH2:6][C:7]1[N:8]=[C:9]([SH:12])[S:10][CH:11]=1)([OH:5])=[O:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178470768HCID 178470768, 화합물

생성물 1

HCID 178525233HCID 178525233, 화합물수율 87.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In 366 ml of water was suspended 185 g (0.91 mol) of 4-ethoxycarbonylmethyl-2-mercaptothiazole and 366 ml (1.84 mols) of an aqueous solution of 5 mol/l sodium hydroxide was added dropwise to the suspension. After heating the mixture for 2 hours in a steam bath with-stirring, the reaction mixture was cooled to room temperature, and 165 ml (1.90 mols) of concentrated hydrochloric acid was added dropwise to the mixture. The crystals formed were collected by filtration under a reduced pressure to provide 139.4 g (yield 87.4%) of 4-carboxymethyl-2-mercaptothiazole.

후처리

  1. additionwas added dropwise to the suspension
  2. temperatureAfter heating the mixture for 2 hours in a steam bath
  3. customThe crystals formed
  4. filtrationwere collected by filtration under a reduced pressure

출처 및 근거

ORD 기록
ord-90a86f7235aa4c3d92910c4a571d06cf
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184386B2

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