Hydroxylamine → 2-METHYL-3-PENTYL ACETATE

HRID 635448노트

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HRID 635448 반응식
NO.[CH:3](=[O:7])[CH:4]([CH3:6])[CH3:5].C([Zn][CH2:11][CH3:12])C.[C:13](OC(=O)C)(=[O:15])[CH3:14]>CCCCCC.C1(C)C=CC=CC=1.ClC1C=CC=CC=1>[C:13]([O:7][CH:3]([CH2:11][CH3:12])[CH:4]([CH3:6])[CH3:5])(=[O:15])[CH3:14]

참가 물질

8

반응물 4

HCID 787HydroxylamineHCID 6561IsobutyraldehydeHCID 7918Acetic AnhydrideHCID 178418750HCID 178418750, 화합물

생성물 1

HCID 5387502-METHYL-3-PENTYL ACETATE수율 92%

시약·촉매·용매 3

HCID 1140Toluene용매HCID 7964Chlorobenzene용매HCID 8058Hexane용매

실험 절차

A vial was charged with aminoalcohol A (0.0057 g, 0.024 mmol). To the vial was added 1.52 mL of a stock solution containing freshly distilled isobutyraldehyde (0.22 g), chlorobenzene internal standard (0.22 g), 1 M diethylzinc in hexane (6.0 mL), and toluene (3.0 mL). After 48 h acetic anhydride (0.200 mL) was added. After an additional 72 h a sample of the solution was analyzed by gas chromatography at 70° C. on a Cyclodex B stationary phase. The product 3-acetoxy-2-methylpentane was formed in 92% yield and 98% enantiomeric excess. The identity and yield of the product was established by comparison with an authentic sample prepared by treatment of racemic 2-methyl-3-pentanol with acetic anhydride.

출처 및 근거

ORD 기록
ord-3f5be64be79d4fe3a578607dcfbbc560
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06187918B1

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