Hydrochloric Acid → 3-Chloro-4-fluorobenzoic acid

HRID 635543

반응식

C[C:2]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([Cl:11])[CH:5]=1)=[O:3].Br[O-].[Na+].S([O-])(O)=[O:16].[Na+].Cl>>[Cl:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[F:10])[C:2]([OH:3])=[O:16]

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 5204223'-Chloro-4'-fluoroacetophenone

HCID 23665763Sodium Bisulfite

HCID 23673712Sodium hypobromite

생성물 1

HCID 5209893-Chloro-4-fluorobenzoic acid수율 74%

실험 절차

The 3-chloro-4-fluoroacetophenone is then reacted with an aqueous solution of sodium hypobromite, the aqeuous phase is treated with sodium hydrogensulfite and acidified with hydrochloric acid, and the precipitated product is recrystallized from benzene. 3-Chloro-4-fluorobenzoic acid obtained in a yield of 74%.

후처리

customthe precipitated product is recrystallized from benzene

출처 및 근거

ORD 기록: ord-d546c0be93c5496da77831fb43df7de5
출처 데이터셋: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06187952B1

연결된 노트

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