Hydrochloric Acid → 3-Chloro-4-fluorobenzoic acid

반응식

C[C:2]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([Cl:11])[CH:5]=1)=[O:3].Br[O-].[Na+].S([O-])(O)=[O:16].[Na+].Cl>>[Cl:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[F:10])[C:2]([OH:3])=[O:16]

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 5204223'-Chloro-4'-fluoroacetophenone

HCID 23665763Sodium Bisulfite

HCID 23673712Sodium hypobromite

생성물 1

HCID 5209893-Chloro-4-fluorobenzoic acid수율 74%

실험 절차

The 3-chloro-4-fluoroacetophenone is then reacted with an aqueous solution of sodium hypobromite, the aqeuous phase is treated with sodium hydrogensulfite and acidified with hydrochloric acid, and the precipitated product is recrystallized from benzene. 3-Chloro-4-fluorobenzoic acid obtained in a yield of 74%.