Acetic Acid → HCID 2775935, 화합물

HRID 635801노트

반응식

HRID 635801 반응식
[S:1]=[C:2]1[CH:7]=[N:6][NH:5][C:4](=[O:8])[NH:3]1.CI.[OH-].[Na+].[C:13](O)(=O)C>O>[CH3:13][S:1][C:2]1[CH:7]=[N:6][NH:5][C:4](=[O:8])[N:3]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 14162865-Thioxo-4,5-dihydro-1,2,4-triazin-3(2H)-one

생성물 1

HCID 2775935HCID 2775935, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The compound 9a (30 g, 232 mmol) and CH3I (15.9 ml, 255 mmol) are placed in 300 ml of water. 18.6 g of NaOH (465 mmol) are added and the mixture is stirred for 1 h at room temperature. The reaction mixture, cooled on a bed of ice, is neutralized using 27 ml of acetic acid and then extracted with dichloromethane. The organic phases are dried (MgSO4) and then concentrated to dryness. After recrystallizing from ether, 29.9 g of compound 9b are isolated.

후처리

  1. temperatureThe reaction mixture, cooled on a bed of ice
  2. extractionextracted with dichloromethane
  3. dry with materialThe organic phases are dried (MgSO4)
  4. concentrationconcentrated to dryness
  5. customAfter recrystallizing from ether, 29.9 g of compound 9b
  6. customare isolated

출처 및 근거

ORD 기록
ord-727fbd0710e5469f87d70ea172070feb
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06191130B1

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