Diethyl Ether → p-Cyclohexylbenzaldehyde

HRID 636152

반응식

HRID 636152 반응식
C1OCCOCCOCCOCCOCCOC1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH:30]1([C:36]2[CH:43]=[CH:42][C:39]([CH2:40][OH:41])=[CH:38][CH:37]=2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.CCOCC>C(Cl)(Cl)Cl>[CH:30]1([C:36]2[CH:37]=[CH:38][C:39]([CH:40]=[O:41])=[CH:42][CH:43]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 2855718-Crown-6HCID 22492024(4-Cyclohexylphenyl)methanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 119689p-Cyclohexylbenzaldehyde

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

18-Crown-6 (Aldrich; 4 molar eq.) and pyridinium chlorochromate (Aldrich; 4 molar eq.) were added together in chloroform and stirred for 20 minutes. 4-Cyclohexylbenzylalcohol (from Example D22 below; 1 molar eq.) was added and stirring continued for 3 hours. Ether was added and the mixture filtered through a plug of silica eluting with ether. The solvent was removed via rotary evaporation. The residue was dissolved in ether and washed with water. The organic layer was dried over Na2SO4, filtered, and concentrated.

후처리

  1. stirringstirring
  2. waitcontinued for 3 hours
  3. filtrationthe mixture filtered through a plug of silica eluting with ether
  4. customThe solvent was removed via rotary evaporation
  5. dissolutionThe residue was dissolved in ether
  6. washwashed with water
  7. dry with materialThe organic layer was dried over Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ad55b80dab7b4b94806b68929f69acf1
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06191166B1

연결된 노트

불러오는 중…