Hydrochloric Acid → 2-chloro-3,4,5-trimethoxybenzoic Acid
반응식
[Cl:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[C:9]([O:16][CH3:17])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[C:9]([O:16][CH3:17])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]참가 물질
5
실험 절차
Combine methyl 2-chloro-3,4,5-trimethoxybenzoate (2.0 g, 7.8 mmol) and a 1 M aqueous solution of sodium hydroxide (100 mL, 100 mmol) in methanol (50 mL). After 6 hours, adjust the pH to about 2 using a 1 M aqueous hydrochloric acid solution and extract with dichloromethane. Dry the combined organic layers over MgSO4, filter, and concentrate in vacuo to give the title compound; Rf=0.81 (silica gel, 10% ethanol/85% chloroform/5% acetic acid).
후처리
- extractionextract with dichloromethane
- dry with materialDry the combined organic layers over MgSO4
- filtrationfilter
- concentrationconcentrate in vacuo
출처 및 근거
- ORD 기록
- ord-9d2c96ef54ce401991bd427456194cf7
- 출처 데이터셋
- uspto-grants-2001_02
- 특허 번호
- US06194406B1
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