Ganciclovir → Ganciclovir Di-O-acetate

HRID 637337

반응식

HRID 637337 반응식
[OH:1][CH2:2][CH:3]([O:6][CH2:7][N:8]1[CH:16]=[N:15][C:14]2[C:13](=[O:17])[NH:12][C:11]([NH2:18])=[N:10][C:9]1=2)[CH2:4][OH:5]>CN(C)C1C=CN=CC=1.C(OC(=O)C)(=O)C>[C:2]([O:1][CH2:2][CH:3]([O:6][CH2:7][N:8]1[CH:16]=[N:15][C:14]2[C:13](=[O:17])[NH:12][C:11]([NH2:18])=[N:10][C:9]1=2)[CH2:4][O:5][C:13](=[O:17])[CH3:14])(=[O:1])[CH3:3]

참가 물질

4

반응물 1

HCID 135398740Ganciclovir

생성물 1

HCID 135459822Ganciclovir Di-O-acetate수율 181.5%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 7918Acetic Anhydride용매

실험 절차

A mixture of 3.00 g of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, 300 mg of 4-dimethylaminopyridine, and 100 ml of acetic anhydride was vigorously stirred for 3 days at room temperature. The acetic anhydride was removed by evaporation at reduced pressure and the residue recrystallized from methanol to give 3.62 g of 9-(1,3-diacetyloxy-2-propoxymethyl)guanine, m.p. 237°-239° C.

후처리

  1. customThe acetic anhydride was removed by evaporation at reduced pressure
  2. customthe residue recrystallized from methanol

출처 및 근거

ORD 기록
ord-6cc821f002e64baa9db9fa54e995b5fd
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04556659

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