Hydrochloric Acid → alpha-Cyclopentyl-p-hydroxybutyrophenone

HRID 637376노트

반응식

HRID 637376 반응식
[CH:1]1([CH:6]([CH2:17][CH3:18])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[CH:11][CH:10]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl-].[Cl-].[Cl-].[Al+3].Cl>C1C=CC=CC=1>[CH:1]1([CH:6]([CH2:17][CH3:18])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 13175264alpha-Cyclopentyl-p-methoxybutyrophenone

생성물 1

HCID 13175265alpha-Cyclopentyl-p-hydroxybutyrophenone

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

The mixture of 4.9 g (0.02 mol) of α-cyclopentyl-p-methoxy butyrophenone, 8.0 g (0.06 mol) of aluminium trichloride and 60 ml of benzene was refluxed for 3 hours. Dilute hydrochloric acid was added, the layers separated and the organic layer washed with water. The product was extracted with 2M sodium hydroxide. The alkaline solution was made acidic. The product was extracted with methylene chloride, dried and the solvent evaporated. The residue 4.1 g (0.018 mol, 88%) was crystallized from petroleum ether. Mp. 75°-78° C.

후처리

  1. temperaturewas refluxed for 3 hours
  2. customthe layers separated
  3. washthe organic layer washed with water
  4. extractionThe product was extracted with 2M sodium hydroxide
  5. extractionThe product was extracted with methylene chloride
  6. customdried
  7. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-8dadc59f99e94a73b861f46460cb8c9b
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04556677

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