Dimethylformamide → 6-(6-Hydroxyhexyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone

HRID 637898

반응식

HRID 637898 반응식
CN(C)[CH:3]=[O:4].[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[C:18]([OH:19])=[C:17]([O:20][CH3:21])[C:16]([O:22][CH3:23])=[CH:15][C:14]=1C>O=O.C1C=C(C=NCCN=CC2C([O-])=CC=CC=2)C([O-])=CC=1.[Co+2]>[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[C:18](=[O:19])[C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[C:3](=[O:4])[C:14]=1[CH3:15]

참가 물질

5

반응물 2

HCID 6228DimethylformamideHCID 202546196-(6-Hydroxyhexyl)-2,3-dimethoxy-5-methylphenol

생성물 1

HCID 128814636-(6-Hydroxyhexyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone

시약·촉매·용매 2

HCID 26517Salcomine촉매HCID 977Oxygen용매

실험 절차

To a dimethylformamide solution (20 ml) of 6-(6-hydroxyhexyl)-2,3-dimethoxy-5-methylphenol (1.5 g) is added bis(salicylidene)ethylenediiminocobalt(II) (15 mg), and the mixture is stirred in oxygen streams at atmospheric temperature and pressure for 72 hours. The reaction product is isolated as in Example 7 and purified by silica gel column chromatography. The ether-hexane (1:1) eluate yields 6-(6-hydroxyhexyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (1.1 g) as orange-yellow oil.

후처리

  1. customThe reaction product is isolated as in Example 7
  2. custompurified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-462b9c8a36eb47669301e031c10faa9d
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04559177

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