Hydrochloric Acid → 5-Oxo-2-pyrrolidinepropanoic acid o-chlorobenzyl ester

HRID 637997

반응식

HRID 637997 반응식
[CH2:1]1[CH:8]2[N:4]([C:5](=[O:9])[CH2:6][CH2:7]2)[C:3](=[O:10])[CH2:2]1.Cl.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][OH:16]>C(OCC)C>[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][O:16][C:5](=[O:9])[CH2:6][CH2:7][CH:8]1[CH2:1][CH2:2][C:3](=[O:10])[NH:4]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 288102-Chlorobenzyl alcoholHCID 71893Rolziracetam

생성물 1

HCID 155888725-Oxo-2-pyrrolidinepropanoic acid o-chlorobenzyl ester

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
100 °C

실험 절차

Five grams of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione (III) are dissolved in 31 g of o-chlorobenzyl alcohol and 0.2 ml of concentrated hydrochloric acid is added. The solution is heated at 100° C. for 71 hours. The mixture is cooled and dissolved in 150 ml of anhydrous diethylether. The solution is cooled to induce crystallization and the resulting crystals are isolated by filtration. Recrystallization from toluene-diethyl ether yields 5-oxo-2-pyrrolidinepropanoic acid o-chlorobenzyl ester with a melting point of 99°-100° C.

후처리

  1. temperatureThe mixture is cooled
  2. temperatureThe solution is cooled
  3. customcrystallization
  4. customthe resulting crystals are isolated by filtration
  5. customRecrystallization from toluene-diethyl ether

출처 및 근거

ORD 기록
ord-d3fb22833c244b4f8cadb28ef832cbb2
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04559358

연결된 노트

불러오는 중…