Hydrochloric Acid → 4-(3,5-Dichloro-pyridin-2-yloxy)-phenol

HRID 638499노트

반응식

HRID 638499 반응식
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.[C:10]1([CH:17]=[CH:16][C:14]([OH:15])=[CH:13][CH:12]=1)[OH:11].[OH-].[K+].Cl>O.CS(C)=O>[Cl:8][C:7]1[C:2]([O:11][C:10]2[CH:17]=[CH:16][C:14]([OH:15])=[CH:13][CH:12]=2)=[N:3][CH:4]=[C:5]([Cl:9])[CH:6]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 785HydroquinoneHCID 14797Potassium HydroxideHCID 27666Pyridine, 2,3,5-trichloro-

생성물 1

HCID 6208804-(3,5-Dichloro-pyridin-2-yloxy)-phenol

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

A mixture of 2,3,5-trichloropyridine (2.5 g, 13.7 mm), hydroquinone (3.02 g, 27.4 mm), KOH (3.07 g, 54.8 mm) and DMSO (10 ml) is heated to 160° for 3 hours. The mixture is poured into water, acidified with dilute HCl and extracted with ether. The ethereal solution is washed, dried and evaporated to dryness. The crude product is chromotographed on silica gel to give crystalline 4-(3,5-dichloropyridyloxy)phenol.

후처리

  1. temperatureis heated to 160° for 3 hours
  2. extractionextracted with ether
  3. washThe ethereal solution is washed
  4. customdried
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-dda42aa49df1418392c21a0d0716d76e
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04561882

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