Sodium Hydroxide → L-Leucine

HRID 638527

반응식

HRID 638527 반응식
C([NH:4][C@H:5]([C:10]([OH:12])=[O:11])[CH2:6][CH:7]([CH3:9])[CH3:8])(=O)C.C(N[C@H](C(O)=O)[C@H](CC)C)(=O)C.[OH-].[Na+]>O>[NH2:4][C@H:5]([C:10]([OH:12])=[O:11])[CH2:6][CH:7]([CH3:9])[CH3:8]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 70912N-Acetyl-L-leucineHCID 7036275N-Acetylisoleucine

생성물 1

HCID 6106L-Leucine

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
36 °C

실험 절차

86.6 grams of this mixture of equal parts of N-acetyl-leucine and N-acetyl-isoleucine were suspended in 400 ml of water and adjusted to pH 7.0 with 50% aqueous sodium hydroxide. There were added 50 mg of CoCl2X6H2O and 50 mg of commerical pig kidney acylase (1200 U/mg) and the mixture was filled up to 500 ml with water. The clear solution was stirred at 36° C. for 6 hours. By filtering with suction, washing and drying there were obtained 17.9 grams of pure L-leucine having a rotary value of [α]D25 =+15.9°.

후처리

  1. additionThere were added 50 mg of CoCl2X6H2O and 50 mg of commerical pig kidney acylase (1200 U/mg)
  2. filtrationBy filtering with suction
  3. washwashing
  4. customdrying there

출처 및 근거

ORD 기록
ord-1d3a85980dba4ee1a0ce9052fe130086
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04562153

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