Hydrochloric Acid → 4-Bromo-6-methoxyquinoline-3-carboxylic acid

HRID 638968노트

반응식

HRID 638968 반응식
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]([O:16]CC)=[O:15].[OH-].[Na+].Cl>C1COCC1>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:14]([OH:16])=[O:15]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 49758155Ethyl 4-bromo-6-methoxyquinoline-3-carboxylate

생성물 1

HCID 684531854-Bromo-6-methoxyquinoline-3-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the ethyl 4-bromo-6-(methyloxy)-3-quinolinecarboxylate (12 g, 38.7 mmol) in THF (120 mL) was added 2N NaOH (45 mL, 90 mmol) dropwise over 15 min. The reaction solution was stirred for 24 h and then neutralized with 2N HCl (pH 6). The THF was removed in vacuo and the resulting aqueous solution was acidified to pH 2. The product was collected by filtration and washed with water and fully dried under vacuum (48 h). Isolated 10.8 g (100%).

후처리

  1. customThe THF was removed in vacuo
  2. filtrationThe product was collected by filtration
  3. washwashed with water
  4. customfully dried under vacuum (48 h)
  5. customIsolated 10.8 g (100%)

출처 및 근거

ORD 기록
ord-fd7ccc8ad6a247368853a454134c76ac
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691850B2

반응 노트

불러오는 중…