Potassium Carbonate → 4-Bromo-1-(cyclopropylmethyl)-1H-pyrazole

HRID 64053

반응식

HRID 64053 반응식
[Br:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:14][CH:15]1[CH2:17][CH2:16]1>CN(C=O)C>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:14][CH:15]2[CH2:17][CH2:16]2)[CH:6]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 163754-BromopyrazoleHCID 81503Bromomethylcyclopropane

생성물 1

HCID 510722584-Bromo-1-(cyclopropylmethyl)-1H-pyrazole수율 109.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-bromo-1H-pyrazole (0.1 g, 0.68 mmol) in DMF (20 ml) were added K2CO3 (0.19 g, 1.36 mmol, 2 eq.) and (bromomethyl)cyclopropane (92 mg, 0.68 mmol, 1 eq.). The mixture was stirred at RT for 4 h. The mixture was quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude product (0.15 g).

후처리

  1. customThe mixture was quenched
  2. extractionextracted as in Intermediate Example 5(c)
  3. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-a167ce228617490a96ee8259ff7c99af
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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