1-Pyrrolidineacetic acid, ethyl ester → Pyrrolidin-1-ylacetic acid

HRID 64066

반응식

HRID 64066 반응식
[N:1]1([CH2:6][C:7]([O:9]CC)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:6][C:7]([OH:9])=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 1

HCID 2109961-Pyrrolidineacetic acid, ethyl ester

생성물 1

HCID 414564Pyrrolidin-1-ylacetic acid수율 91%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The solution of ethyl 2-(pyrrolidin-1-yl)acetate (2 g, 12.7 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 91% yield (1.5 g). LC-MS (ESI): Calculated mass: 129.1; Observed mass 130.1 [M+H+] (rt: 0.26 min).

후처리

  1. concentrationThe mixture was concentrated
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 91% yield (1.5 g)
  6. customObserved mass 130.1 [M+H+] (rt: 0.26 min)

출처 및 근거

ORD 기록
ord-4fed8b6380b94254a92f74f824b0f9b3
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447091B2

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