Hydrazine hydrate (1:1) → Benzofuran-7-amine

HRID 641756노트

반응식

HRID 641756 반응식
O.NN.[N+:4]([C:7]1[C:15]2[O:14][CH:13]=[CH:12][C:11]=2[CH:10]=[CH:9][CH:8]=1)([O-])=O>[Ni].CO>[NH2:4][C:7]1[C:15]2[O:14][CH:13]=[CH:12][C:11]=2[CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 112866387-Nitrobenzofuran

생성물 1

HCID 11217277Benzofuran-7-amine수율 98%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

반응 조건

온도
55 °C

실험 절차

Hydrazine hydrate (0.45 ml) was added dropwise to a stirred mixture of 7-nitrobenzofuran (J. Med. Chem., 1988, 31, 1934; 0.5 g), Raney nickel (0.02 g) and methanol (9 ml) that had been warmed to 55° C. The resultant mixture was heated to reflux for 30 minutes. The catalyst was removed by filtration and the filtrate was evaporated. The residue was partitioned between methylene chloride and water. The organic phase was dried over magnesium sulphate and evaporated to give 7-aminobenzofuran (0.4 g) as an oil; NMR Spectrum: (DMSOd6) 5.25 (br s, 2H), 6.55 (d, 1H), 6.8 (m, 2H), 6.9 (t, 1H), 7.85 (d, 1H).

후처리

  1. temperatureto reflux for 30 minutes
  2. customThe catalyst was removed by filtration
  3. customthe filtrate was evaporated
  4. customThe residue was partitioned between methylene chloride and water
  5. dry with materialThe organic phase was dried over magnesium sulphate
  6. customevaporated

출처 및 근거

ORD 기록
ord-0a8b6475a9754a9bb1a66d1e6bf89d96
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696214B2

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