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Hydrochloric Acid → 4-Methyl-3-[6-(4-morpholinylmethyl)-4-oxo-3(4H)-quinazolinyl]benzoic acid

HRID 641991
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HRID 641991 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[N:12]1[C:21](=[O:22])[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([CH2:23][N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[CH:19]=2)[N:14]=[CH:13]1.[OH-].[Na+].Cl>CO.O>[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N:12]1[C:21](=[O:22])[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([CH2:23][N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[CH:19]=2)[N:14]=[CH:13]1
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참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68515979HCID 68515979, 화합물

생성물 1

HCID 685167144-Methyl-3-[6-(4-morpholinylmethyl)-4-oxo-3(4H)-quinazolinyl]benzoic acid수율 100.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water
용매

실험 절차

To a solution of methyl 4-methyl-3-[6-(morpholin-4-ylmethyl)-4-oxoquinazolin-3(4H)-yl]benzoate (0.62 g) in methanol (10 ml) and water (4 ml) was added 2N NaOH (2.35 ml) and stirred at room temperature for 4 hours. 1N HCl was added and the reaction was allowed to stand for 16 hours and then concentrated. The residue was dissolved in methanol (40 ml), inorganics removed by filtration. The filtrate concentrated to give 4-methyl-3-[6-(morpholin-4-ylmethyl)-4-oxoquinazolin-3(4H)-yl]benzoic acid as a solid (0.60 g). Mass Spectrum: M+H+ 380.

후처리

  1. waitto stand for 16 hours
  2. concentrationconcentrated
  3. dissolutionThe residue was dissolved in methanol (40 ml)
  4. custominorganics removed by filtration
  5. concentrationThe filtrate concentrated

출처 및 근거

ORD 기록
ord-0015576713cc42e1b696593d5d9f3cc8
출처 데이터셋
uspto-grants-2010_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07696215B2

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