Hydrochloric Acid → 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one

HRID 642921

반응식

HRID 642921 반응식
[CH3:1][N:2]1[C:14]2[CH2:13][CH2:12][CH2:11][C:10](=[O:15])[C:9]=2[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.C=O.Cl.[CH3:19]N(C=O)C>C(O)(=O)C>[CH3:1][N:2]1[C:14]2[CH2:13][CH2:12][C:11](=[CH2:19])[C:10](=[O:15])[C:9]=2[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 6228DimethylformamideHCID 5988759-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

생성물 1

HCID 117905051,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Accordingly, 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one was synthesized from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one using a formaldehyde reagent (paraformaldehyde) and a mineral acid (HCl) in an aprotic solvent (DMF). Note that this reaction was rapid and high yielding, even though it was performed without using glacial acetic acid as a solvent, and without using a secondary amine as a catalyst.

출처 및 근거

ORD 기록
ord-1aef5c842c6b48729cb0ba28b1f33527
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07696356B2

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