Benzyl mercaptan → 2-Benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene

HRID 64556

반응식

HRID 64556 반응식
[CH2:1]([SH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[Cl:11][C:12]1[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][C:13]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[C:17]([N+]([O-])=O)[CH:16]=1>O1CCCC1>[CH2:1]([S:8][C:17]1[CH:16]=[C:15]([O:14][C:13]2[CH:27]=[CH:28][C:29]([C:31]([F:34])([F:32])[F:33])=[CH:30][C:12]=2[Cl:11])[CH:20]=[CH:19][C:18]=1[N+:21]([O-:23])=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7509Benzyl mercaptanHCID 24758Sodium hydrideHCID 156238Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)-

생성물 1

HCID 202362812-Benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

1.7 g of benzyl mercaptan was dissolved in dry tetrahydrofuran and 0.5 g of sodium hydride added with stirring under dry nitrogen. The reaction mixture was stirred under reflux for 30 minutes, and a solution of 5 g of 1A dissolved in 25 ml of dry tetrahydrofuran was added dropwise. Reaction occurred rapidly, and the product was chromatographically purified to give 2-benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene (1B) as a yellow oil.

후처리

  1. stirringThe reaction mixture was stirred
  2. temperatureunder reflux for 30 minutes
  3. additionwas added dropwise
  4. customReaction
  5. customthe product was chromatographically purified

출처 및 근거

ORD 기록
ord-a90262bdbc264b34851ba14fae0a069f
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609394

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