Hydrochloric Acid → 2-(4-Bromophenoxy)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one

HRID 646124노트

반응식

HRID 646124 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]([CH3:17])([CH3:16])[C:13](Cl)=[O:14])=[CH:9][CH:8]=1.Cl>CC#N.[Cl-].[Na+].O>[Br:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]([CH3:16])([CH3:17])[C:13]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:14])=[CH:9][CH:8]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 31268PyrrolidineHCID 45923264HCID 45923264, 화합물

생성물 1

HCID 686947812-(4-Bromophenoxy)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one수율 94.3%

시약·촉매·용매 2

HCID 6342Acetonitrile용매2회HCID 57417360Sodium chloride; water용매

실험 절차

Pyrrolidine (1.54 g, 21.6 mmol) in anhydrous MeCN (10 mL) was added with stirring to 2-(4-bromophenoxy)-2-methylpropanoyl chloride (2 g, 7.2 mmol) in anhydrous MeCN (10 mL) at 0° C. The mixture was stirred at room temperature for 18 h and acidified with HCl (aq. 1M, 40 mL). Brine was added and the mixture was extracted with CH2Cl2. The combined extracts were washed with NaHCO3 (aq. sat) and brine, dried (Na2SO4), and concentrated to give the sub-title compound (2.12 g, 94%).

후처리

  1. extractionthe mixture was extracted with CH2Cl2
  2. washThe combined extracts were washed with NaHCO3 (aq. sat) and brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1a2c603c73604cefa9e76b385285ffd3
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705023B2

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