Hydrochloric Acid → 1-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine hydrochloride

HRID 646127노트

반응식

HRID 646127 반응식
[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([Cl:10])=[O:9])=[CH:4][CH:3]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.Cl>CCOCC.O1CCOCC1>[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[O:9])=[CH:4][CH:3]=1.[ClH:10].[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([N:19]2[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]2)=[O:9])=[CH:4][CH:3]=1

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 45923264HCID 45923264, 화합물

생성물 2

HCID 686975001-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine hydrochloride수율 95%HCID 68697501HCID 68697501, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

실험 절차

1-(2-(4-Bromophenoxy)-2-methylpropanoyl)-4-methylpiperazine was prepared in accordance to the procedure described in Example 29(a) from 2-(4-bromophenoxy)-2-methylpropanoyl chloride and 1-methylpiperazine (5.3 mL, 17.5 mmol). This compound (2.37 g, 6.95 mmol) was dissolved in Et2O and HCl in dioxane (4M, 2.26 mL) was added dropwise with stirring. The precipitate was filtered off and dried to yield the sub-title compound (2.5 g, 95%).

후처리

  1. filtrationThe precipitate was filtered off
  2. customdried

출처 및 근거

ORD 기록
ord-0b005888c89b4786a135e67675814dcd
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705023B2

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