Sodium Hydroxide → 4-Hydroxycarbazole

HRID 646647

반응식

HRID 646647 반응식
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[C:4](=[O:14])[CH2:3][CH2:2]1.[OH-].[Na+]>[Ni].O>[OH:14][C:4]1[C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[NH:12][C:13]=2[CH:1]=[CH:2][CH:3]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 9291301,2,3,9-Tetrahydro-4H-carbazol-4-one

생성물 1

HCID 1042514-Hydroxycarbazole

시약·촉매·용매 2

HCID 935Nickel촉매HCID 962Water용매

실험 절차

To a reactor containing water (1 L) was added Raney nickel (35 g) followed by 1,2,3,9-tetrahydrocarbazole-4-one (50 g) and sodium hydroxide (15 g). The contents were heated to reflux and maintained for about 20 hours. The catalyst was filtered off and the filtrate was acidified to obtain a solid, which was filtered and dried to obtain the title compound. When necessary, the title compound was further purified by dissolving in 10% sodium hydroxide solution, treating with activated charcoal and precipitation from dilute hydrochloric acid to give off-white to grey crystals of 4-hydroxy carbazole in 50% yield.

후처리

  1. temperatureThe contents were heated
  2. temperatureto reflux
  3. temperaturemaintained for about 20 hours
  4. filtrationThe catalyst was filtered off
  5. customto obtain a solid, which
  6. filtrationwas filtered
  7. customdried

출처 및 근거

ORD 기록
ord-8478a4ba9d0a4efe8b2edf31f4d6d925
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705163B2

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