4-Methylpiperidine → 1-(5-Chloro-2-nitro-phenyl)-4-methyl-piperidine

HRID 646855

반응식

HRID 646855 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[CH:3]=1.[CH3:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>CCO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([N:16]2[CH2:17][CH2:18][CH:13]([CH3:12])[CH2:14][CH2:15]2)[CH:3]=1

참가 물질

4

반응물 2

HCID 693814-MethylpiperidineHCID 696914-Chloro-2-fluoro-1-nitrobenzene

생성물 1

HCID 586385011-(5-Chloro-2-nitro-phenyl)-4-methyl-piperidine수율 99.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The procedure of Example 4, step (a) was followed using 0.950 g (5.43 mmol) of 4-chloro-2-fluoronitrobenzene and 1.93 mL (16.3 mmol) of 4-methylpiperidine in 10 mL of EtOH to afford 1.37 g (99%) of the title compound as an orange oil which crystallized on standing: Mass spectrum (ESI, m/z): Calcd. for C12H15ClN2O2, 255.1 (M+H), found 255.0.

출처 및 근거

ORD 기록
ord-753252e58d0c4122b412b699fcd85a87
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07705042B2

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