4-Hydroxybiphenyl → 4-Chloro-(4-biphenylyloxy)-2-butanol

HRID 64693

반응식

HRID 64693 반응식
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl[CH2:17][CH:18]([OH:22])[CH2:19][CH2:20][Cl:21]>O>[Cl:21][CH2:20][CH2:19][CH:18]([OH:22])[CH2:17][O:13][C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 71034-HydroxybiphenylHCID 14798Sodium HydroxideHCID 170211,4-Dichloro-2-butanol

생성물 1

HCID 131203474-Chloro-(4-biphenylyloxy)-2-butanol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

To a solution of 1 mole (158 g.) of 4-phenylphenol 100 g. of sodium hydroxide and 500 ml. of water was added 1 mole (143.02 g.) of 1,4-dichloro-2-butanol with stirring at 40° C. The resulting mixture was heated at 68° C. in a steam bath for 6 hr., cooled and extracted with 300 ml. of chloroform. The chloroform extract was washed with water to neutrality, dried over sodium sulfate and concentrated to dryness. The solid residue was recrystallized with isopropanol and yielded 180 g. of a white crystalline solid which melted at 123°-124° C.

후처리

  1. temperatureThe resulting mixture was heated at 68° C. in a steam bath for 6 hr
  2. temperature, cooled
  3. extractionextracted with 300 ml
  4. extractionThe chloroform extract
  5. washwas washed with water to neutrality
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated to dryness
  8. customThe solid residue was recrystallized with isopropanol
  9. customyielded 180 g

출처 및 근거

ORD 기록
ord-502be600990d42969ee862e5f8dd42f5
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04609735

연결된 노트

불러오는 중…