Dl-Phenylalanine → D-phenylalanine N-carbobenzoxy-D-aspartic acid

HRID 64785

반응식

HRID 64785 반응식
[NH2:1][CH:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.S(=O)(=O)(O)O.[C:18]([NH:28][C@@H:29]([C:34]([OH:36])=[O:35])[CH2:30][C:31]([OH:33])=[O:32])([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19]>O>[C:18]([NH:28][C@@H:29]([C:34]([OH:36])=[O:35])[CH2:30][C:31]([OH:33])=[O:32])([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19].[NH2:1][C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 994Dl-PhenylalanineHCID 1118Sulfuric AcidHCID 5289152(2R)-2-(((benzyloxy)carbonyl)amino)butanedioic acid

생성물 1

HCID 13714281D-phenylalanine N-carbobenzoxy-D-aspartic acid수율 32.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Eight grams of DL-phenylalanine and 1.2 g of sulfuric acid was suspended in 100 ml of water at 40° C. Ten grams of N-carbobenzoxy-D-aspartic acid was added to the solution over five hours, while this solution was continuously stirred. The resulting crystal was separated, washed with 10 ml of water and dried to give 5.2 g of a D-phenylalanine N-carbobenzoxy-D-aspartic acid. Analysis revealed that the optical purity of the D-phenylalnine was 98%.

후처리

  1. customThe resulting crystal was separated
  2. washwashed with 10 ml of water
  3. customdried

출처 및 근거

ORD 기록
ord-987bea95ecff469face1ae081f9f5f8e
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04610827

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