p-Anisoyl chloride → HCID 13371227, 화합물

HRID 64866

반응식

HRID 64866 반응식
[N:1]1([CH2:7][C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:16]([Cl:26])(=[O:25])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1>C(Cl)Cl.C(O)(C)C>[ClH:26].[CH3:24][O:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]([N:4]2[CH2:3][CH2:2][N:1]([CH2:7][C:8]([N:10]3[CH2:11][CH2:12][O:13][CH2:14][CH2:15]3)=[O:9])[CH2:6][CH2:5]2)=[O:25])=[CH:18][CH:19]=1

참가 물질

5

반응물 2

HCID 7477p-Anisoyl chlorideHCID 1006221-(Morpholinocarbonylmethyl)piperazine

생성물 1

HCID 13371227HCID 13371227, 화합물

시약·촉매·용매 2

HCID 3776Isopropanol용매HCID 6344Dichloromethane용매

실험 절차

10.25 g of piperazin-1-yl-acetic acid morpholide are cooled to 0° C. in 20 ml of methylene chloride. 8.75 g of anisoyl chloride are added dropwise in the course of 15 minutes. After the mixture has been subsequently stirred for 4 hours, it is diluted with isopropanol, whereupon the colourless product precipitates. It is filtered off with suction and dried.

후처리

  1. customprecipitates
  2. filtrationIt is filtered off with suction
  3. customdried

출처 및 근거

ORD 기록
ord-21ca3ae338254865a0d42275bcf052d1
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04610984

연결된 노트

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