p-Anisoyl chloride → 4-(4-Methoxybenzoyl)-piperazin-1-yl-acetic acid pyrrolidide hydrochloride

HRID 64868

반응식

HRID 64868 반응식
[N:1]1([CH2:7][C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:15]([Cl:25])(=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1>C(Cl)Cl>[ClH:25].[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([C:15]([N:4]2[CH2:3][CH2:2][N:1]([CH2:7][C:8]([N:10]3[CH2:11][CH2:12][CH2:13][CH2:14]3)=[O:9])[CH2:6][CH2:5]2)=[O:24])=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 7477p-Anisoyl chlorideHCID 1006141-((Pyrrolidine-1-carbonyl)methyl)piperazine

생성물 1

HCID 133712294-(4-Methoxybenzoyl)-piperazin-1-yl-acetic acid pyrrolidide hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
25 °C

실험 절차

9.4 g of piperazin-1-yl-acetic acid pyrrolidide are dissolved in 10 ml of methylene chloride. A solution of 8.75 g of anisic acid chloride in 10 ml of methylene chloride is added dropwise at 0°. After the mixture had been stirred at 25° C. for 60 minutes, the crystals are filtered off with suction and dried in vacuo.

후처리

  1. filtrationthe crystals are filtered off with suction
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-4b04545c2c6a4b479b8c744174660109
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04610984

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