1-Iodopropane → 3-Methoxy-2-methyl-4-propoxypyridine

HRID 649208

반응식

HRID 649208 반응식
[CH3:1][O:2][C:3]1[C:8](=[O:9])[CH:7]=[CH:6][NH:5][C:4]=1[CH3:10].[CH2:11](I)[CH2:12][CH3:13]>CN(C)C=O.C(Cl)(Cl)Cl.[Ag]=O>[CH3:1][O:2][C:3]1[C:4]([CH3:10])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:11][CH2:12][CH3:13]

참가 물질

6

반응물 2

HCID 336431-IodopropaneHCID 3234243-Methoxy-2-methyl-1H-pyridin-4-one

생성물 1

HCID 139829483-Methoxy-2-methyl-4-propoxypyridine

시약·촉매·용매 3

HCID 92152Silver(II) oxide촉매HCID 6212Chloroform용매HCID 6228Dimethylformamide용매

실험 절차

3-Methoxy-2-methyl-4(1H)-pyridone(1.39 g) and propyl iodide (2.0 ml) were dissolved in dimethylformamide (20 ml), to which silver oxide (2.31 g) was added in small portions and stirred vigorously at room temperature for 5 hours. The reaction mixture was diluted with chloroform (100 ml), washed with water, dried and evaporated. The residue was purified by flash chromatography (chloroform) on silica gel, to give 3-methoxy-2-methyl-4-propoxypyridine (1.7 g) as a light brown oil.

후처리

  1. additionwas added in small portions
  2. washwashed with water
  3. customdried
  4. customevaporated
  5. customThe residue was purified by flash chromatography (chloroform) on silica gel

출처 및 근거

ORD 기록
ord-2a493dc1dce0447e91aa00ee831790d4
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04738975

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