Hydrochloric Acid → 4-Dimethylaminobenzyl alcohol
반응식
[CH3:1][N:2]([CH3:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[O:8])=[CH:5][CH:4]=1.[BH4-].[Na+].Cl>C(O)C>[CH3:1][N:2]([CH3:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7][OH:8])=[CH:5][CH:4]=1참가 물질
5
실험 절차
Mix 4-dimethylaminobenzaldehyde (3.3 g, 22 mmol), sodium borohydride (830 mg, 22 mmol) and absolute ethanol (25 mL). Stir at room temperature until the reaction is complete, pour onto dilute hydrochloric acid and extract into ethyl acetate. Separate the organic phase and extract the aqueous phase with ethyl acetate (2×). Combine the organic phases and dry (MgSO4). Evaporate the solvent in vacuo and purify by silica gel chromatography to give 4-(dimethylamino)benzyl alcohol.
후처리
- extractionextract into ethyl acetate
- customSeparate the organic phase
- extractionextract the aqueous phase with ethyl acetate (2×)
- dry with materialCombine the organic phases and dry (MgSO4)
- customEvaporate the solvent in vacuo
- custompurify by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-d66256aab42c4645ba01c94ac4791f03
- 출처 데이터셋
- uspto-grants-1993_09
- 특허 번호
- US05248825
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