Hydrochloric Acid → 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid

HRID 649864

반응식

HRID 649864 반응식
C[O:2][C:3]([C:5]1[S:9][N:8]=[N:7][C:6]=1[CH3:10])=[O:4].[OH-].[Na+].Cl>CO>[CH3:10][C:6]1[N:7]=[N:8][S:9][C:5]=1[C:3]([OH:4])=[O:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 7576666Methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate

생성물 1

HCID 13819924-Methyl-1,2,3-thiadiazole-5-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid methyl ester (1.7 g) is dissolved in methanol (15 mL) and treated with 1N sodium hydroxide (16 mL). After stirring at room temperature for 1 hour, the reaction is treated with concentrated hydrochloric acid (1.5 mL) and concentrated under reduced pressure. The resulting turbid aqueous layer is extracted twice with diethyl ether and the pooled organic layers are dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the desired compound as a white powder.

후처리

  1. concentrationconcentrated under reduced pressure
  2. extractionThe resulting turbid aqueous layer is extracted twice with diethyl ether
  3. dry with materialthe pooled organic layers are dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3a3e4431c7854b1cb2bf23ba0601180c
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271236B1

연결된 노트

불러오는 중…