Hydrochloric Acid → 4-Methyl-1,2,3-thiadiazole-5-carboxylic acid
반응식
C[O:2][C:3]([C:5]1[S:9][N:8]=[N:7][C:6]=1[CH3:10])=[O:4].[OH-].[Na+].Cl>CO>[CH3:10][C:6]1[N:7]=[N:8][S:9][C:5]=1[C:3]([OH:4])=[O:2]참가 물질
5
실험 절차
4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid methyl ester (1.7 g) is dissolved in methanol (15 mL) and treated with 1N sodium hydroxide (16 mL). After stirring at room temperature for 1 hour, the reaction is treated with concentrated hydrochloric acid (1.5 mL) and concentrated under reduced pressure. The resulting turbid aqueous layer is extracted twice with diethyl ether and the pooled organic layers are dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the desired compound as a white powder.
후처리
- concentrationconcentrated under reduced pressure
- extractionThe resulting turbid aqueous layer is extracted twice with diethyl ether
- dry with materialthe pooled organic layers are dried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-3a3e4431c7854b1cb2bf23ba0601180c
- 출처 데이터셋
- uspto-grants-2001_08
- 특허 번호
- US06271236B1
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