Anisole → 9-methoxy-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine

HRID 649936노트

반응식

HRID 649936 반응식
[NH2:1][C:2]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:3]=1[NH:4][C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[C:6]=1[C:14](OCC)=O.[CH3:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1.C1(OC)C=CC=CC=1>[Ti](Cl)(Cl)(Cl)Cl>[CH3:24][O:23][C:21]1[CH:20]=[CH:19][C:3]2[NH:4][C:5]3[S:9][C:8]4[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=4[C:6]=3[C:14]([N:29]3[CH2:30][CH2:31][N:26]([CH3:25])[CH2:27][CH2:28]3)=[N:1][C:2]=2[CH:22]=1

참가 물질

5

반응물 3

HCID 7519AnisoleHCID 531671-MethylpiperazineHCID 18422191Ethyl 2-(2-amino-4-methoxy-anilino)benzo[b]thiophene-3-carboxylate

생성물 1

HCID 1358164179-methoxy-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine

시약·촉매·용매 1

HCID 24193Titanium Tetrachloride촉매

실험 절차

In the same manner as in Example 1 and using ethyl 2-(2-amino-4-methoxy-anilino)benzo[b]thiophene-3-carboxylate, 1-methylpiperazine, anisole and titanium tetrachloride, 9-methoxy-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.

출처 및 근거

ORD 기록
ord-9c4d826cb29648f296b51e4375ad7209
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271225B1

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