1,2-Dichloroethane → 2-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

HRID 650002노트

반응식

HRID 650002 반응식
[S:1]1[C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=[CH:2]1.ClCCCl.[C:20](Cl)(=[O:22])[CH3:21].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)(Cl)Cl>[C:20]([C:2]1[S:1][C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=1)(=[O:22])[CH3:21]

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 18422172Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one

생성물 1

HCID 184223372-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one (5 g) was suspended to 1,2-dichloroethane (50 ml) and acetyl chloride was added (2.2 g). To this reaction system was added portionwise aluminum chloride (15 g) under ice-cooling and the mixture was stirred at room temperature for 10 minutes. The reaction system was poured into ice. Chloroform was added and the mixture was stirred for 15 minutes. The precipitated crystals were collected by filtration to give 2-acetylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one (5.2 g).

후처리

  1. additionwas added (2.2 g)
  2. temperaturecooling
  3. additionThe reaction system was poured into ice
  4. stirringthe mixture was stirred for 15 minutes
  5. filtrationThe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-8a9a0fab71fd41de85f86f46ccd60960
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271225B1

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