Indene → 2-[3,5-Bis(trifluoromethyl)phenyl]-1H-indene

HRID 650304노트

반응식

HRID 650304 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.I[C:11]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=1>CC([O-])=O.CC([O-])=O.[Pd+2].C(N(CC)CC)C>[F:18][C:17]([F:19])([F:20])[C:15]1[CH:16]=[C:11]([C:2]2[CH2:3][C:4]3[C:9]([CH:1]=2)=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH:12]=[C:13]([C:21]([F:22])([F:23])[F:24])[CH:14]=1

참가 물질

5

반응물 2

HCID 7219IndeneHCID 6309701-Iodo-3,5-bis(trifluoromethyl)benzene

생성물 1

HCID 120106252-[3,5-Bis(trifluoromethyl)phenyl]-1H-indene

시약·촉매·용매 2

HCID 167845palladium(II) acetate촉매HCID 8471Triethylamine용매

실험 절차

20 ml of triethylamine, 2.2 g (20 mmole) of indene, 6.8 g (20 mmole) of 1-iodo-3,5-bis(trifluoromethyl)-benzene and 0.134 g (0.6 mmole) and 0.134 g (0.6 mmole) of Pd(OAc)2 were stirred under relux for 12 h. After it all triethylamine was removed under reduced pressure. The residue was treated with the mixture 50 ml of water and 50 ml of diethyl ether.

후처리

  1. customAfter it all triethylamine was removed under reduced pressure
  2. additionThe residue was treated with the mixture 50 ml of water and 50 ml of diethyl ether

출처 및 근거

ORD 기록
ord-f1e9133ef0e54f7295b0c949d591a90e
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06271411B1

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