반응식
[OH:1][CH2:2][C@@H:3]1[CH2:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH2:5][NH:4]1.[OH-].[Na+].[C:18](=[S:20])=[S:19].[C:21]1([CH2:26]Cl)[S:25][CH:24]=[CH:23][CH:22]=1>CO.C(O)C>[OH:1][CH2:2][C@@H:3]1[CH2:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH2:5][N:4]1[C:18]([S:20][CH2:26][C:21]1[S:25][CH:24]=[CH:23][CH:22]=1)=[S:19]참가 물질
7
반응물 4
생성물 1
시약·촉매·용매 2
실험 절차
In the same manner as described in Example 8 by using (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline (2.02 g), 2N NaOH (10 ml), CS2 (1.5 g), 2-Thenyl chloride (2.65 g), and 80% ethanol (50 ml), there is prepared the title compound (1.86 g, 50%) as white powder, [α]D20 +108.4° (c=1.0, methanol). NMR (CDCl3, δ): 4.84 (s, 2H, CSSCH2 -- ##STR8## Mass m/e: 374 (M+), 244 (M+ -- ##STR9##
출처 및 근거
- ORD 기록
- ord-05d2ece3443f4bf7b151e7c045d5cf27
- 출처 데이터셋
- uspto-grants-1986_09
- 특허 번호
- US04612317
연결된 노트
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