Hydrochloric Acid → (S)-(+)-3-Cyano-4-(2-methylbutyloxy)phenylboronic acid

HRID 651308노트

반응식

HRID 651308 반응식
[Li].[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14][C@@H:15]([CH3:18])[CH2:16][CH3:17])C(O)=O)#[N:3].[B:19](OC)([O:22]C)[O:20]C.Cl>C1COCC1>[C:2]([C:4]1[CH:5]=[C:6]([B:19]([OH:22])[OH:20])[CH:10]=[CH:11][C:12]=1[O:13][CH2:14][C@@H:15]([CH3:18])[CH2:16][CH3:17])#[N:3]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8470Trimethyl borateHCID 3028194Lithium2회HCID 54501986(S)-(+)-3-Cyano-4-(2-methylbutyloxy)benzoic acid

생성물 1

HCID 53923893(S)-(+)-3-Cyano-4-(2-methylbutyloxy)phenylboronic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The experimental procedure for the preparation of the lithium salt was as described in the preparation of compound 43. A solution of trimethyl borate (2.70 g, 0.024 mol) in dry THF (10 ml) was added dropwise to the lithium salt solution. The resultant mixture was allowed to warm to room temperature overnight whilst stirring and dilute hydrochloric acid was then added. The THF/water azeotrope was removed in vacuo and the remaining residue was dissolved in diethyl ether and washed with water until acid-free. The ether was dried (MgSO4) and removed in vacuo to leave a fawn solid.

후처리

  1. customThe THF/water azeotrope was removed in vacuo
  2. dissolutionthe remaining residue was dissolved in diethyl ether
  3. washwashed with water until acid-free
  4. dry with materialThe ether was dried (MgSO4)
  5. customremoved in vacuo
  6. customto leave a fawn solid

출처 및 근거

ORD 기록
ord-fafe30abe6ee4814819541f97cf2c224
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06278028B1

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