Methanol → Methyl isobutyrate

HRID 65140

반응식

HRID 65140 반응식
F[C:2](F)(F)[C:3]1[CH:8]=CC=C[C:4]=1P([C:16]1[CH:21]=CC=CC=1)C1C=CC=CC=1.C[OH:25].[O:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>[Pd](Cl)Cl>[C:4]([O:26][CH3:27])(=[O:25])[CH:3]([CH3:8])[CH3:2].[C:30]([O:29][CH3:28])(=[O:25])[CH2:31][CH2:21][CH3:16]

참가 물질

6

반응물 3

HCID 887MethanolHCID 312751,4-DioxaneHCID 303893Diphenyl[2-(trifluoromethyl)phenyl]phosphane

생성물 2

HCID 11039Methyl isobutyrateHCID 12180Methyl butyrate

시약·촉매·용매 1

HCID 24290Palladium Chloride촉매

반응 조건

온도
120 °C

실험 절차

The autoclave was charged with 0.3 gms of palladium chloride, 5 gms o-trifluoromethylphenyldiphenylphosphine, 10 mls of methanol and 50 ml of p-dioxane. After flushing with nitrogen, the autoclave was pressurized with carbon monoxide to 800 psig and heated to 120 degrees C. with stirring. 10 gms of liquid propylene was added and the reaction continued at 120° C. and 100 psig for 3 hours. The autoclave was then cooled and the reaction fluid analyzed by gas chromatography. A methyl isobutyrate:methyl n-butyrate ratio of 7.1:1 was obtained.

후처리

  1. customAfter flushing with nitrogen
  2. addition10 gms of liquid propylene was added
  3. customcontinued at 120° C.
  4. temperatureThe autoclave was then cooled

출처 및 근거

ORD 기록
ord-e5490df9d8cf467daca53ea437840a1c
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04612390

연결된 노트

불러오는 중…