Water → Ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate

HRID 65180

반응식

HRID 65180 반응식
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[O:3].[C:8](=[O:18])([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[NH2:9].O>C1(C)C=CC=CC=1>[CH2:11]([O:10][C:8]([NH:9][CH:2]([OH:3])[C:1]([O:5][CH2:6][CH3:7])=[O:4])=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 12136Benzyl carbamateHCID 70211Ethyl oxoacetate

생성물 1

HCID 20233481Ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate수율 64.9%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 17.3 g (0.169 mole) of ethyl glyoxylate and 23.0 g (0.152 mole) of benzyl carbamate in 250 ml of toluene was heated under reflux for 6 hours, with removal of water using a Dean-Stark trap. The resulting reaction mixture was concentrated in vacuo, and diethyl ether was added to the residue. The mixture was filtered, and the diethyl ether solution was evaporated in vacuo to give 25.0 g of ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate as a sticky solid.

후처리

  1. customThe resulting reaction mixture
  2. concentrationwas concentrated in vacuo, and diethyl ether
  3. additionwas added to the residue
  4. filtrationThe mixture was filtered
  5. customthe diethyl ether solution was evaporated in vacuo

출처 및 근거

ORD 기록
ord-302a40ecef4448ebbe1ad41a616bb359
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04613462

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