Sodium Hydroxide → N-[4-[14-(Trimethylsilyl)tetradecylamino]benzoyl)glycine

HRID 652032

반응식

HRID 652032 반응식
[CH3:1][Si:2]([CH3:34])([CH3:33])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:32]=[CH:31][C:21]([C:22](=[O:30])[NH:23][CH2:24][C:25]([O:27]CC)=[O:26])=[CH:20][CH:19]=1.[OH-].[Na+]>C(O)C>[CH3:34][Si:2]([CH3:1])([CH3:33])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([NH:23][CH2:24][C:25]([OH:27])=[O:26])=[O:30])=[CH:31][CH:32]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20198242Ethyl 4-[14-(trimethylsilyl)tetradecylamino]hippurate

생성물 1

HCID 20198286N-[4-[14-(Trimethylsilyl)tetradecylamino]benzoyl)glycine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 12.5 g. of ethyl 4-[14-(trimethylsilyl)tetradecylamino]hippurate, 55 ml. of 1N sodium hydroxide solutions and 50 ml. of ethanol is stirred at ambient temperature for 2 hours and then partially evaporated. The aqueous solution is washed with diethyl ether, acidified with 6N hydrochloric acid, and filtered. The solid is dried in vacuo and recrystallized to yield the product as a white solid.

후처리

  1. additionA mixture of 12.5 g
  2. custompartially evaporated
  3. washThe aqueous solution is washed with diethyl ether
  4. filtrationfiltered
  5. customThe solid is dried in vacuo
  6. customrecrystallized

출처 및 근거

ORD 기록
ord-51d702da3ab148408fdf35a26672fdea
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04670421

연결된 노트

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