Hydrazine hydrate (1:1) → HCID 178480237, 화합물

HRID 652129

반응식

HRID 652129 반응식
F[C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=O.O.[NH2:18][NH2:19]>O>[CH3:12][N:9]1[CH2:10][CH2:11][CH:6]([C:4]2[C:3]3[C:2](=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:19][N:18]=2)[CH2:7][CH2:8]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 131803174-(2-Fluorobenzoyl)-1-methylpiperidine

생성물 1

HCID 178480237HCID 178480237, 화합물수율 23.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

An autoclave was charged with 10.0 g of 4-(2-fluorobenzoyl)-1-methylpiperidine and 14 ml of hydrazine hydrate. The reaction was heated at 150° for 20 hrs, cooled, and poured into water. The resultant solid was collected. The solid was recrystallized twice from toluene to yield 2.4 g (23.7%) of product, mp 168°-170° C.

후처리

  1. temperatureThe reaction was heated at 150° for 20 hrs
  2. temperaturecooled
  3. customThe resultant solid was collected
  4. customThe solid was recrystallized twice from toluene

출처 및 근거

ORD 기록
ord-cdd33599bdaa477e8b872b2930c887a2
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04670447

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