Hydrochloric Acid → Methanesulfonamide, N-[4-(2-chloroacetyl)phenyl]-

HRID 65238

반응식

HRID 65238 반응식
[C:1]1([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:12][CH2:13][C:14](Cl)=[O:15].[Cl-].[Al+3].[Cl-].[Cl-].Cl>C(Cl)Cl>[Cl:12][CH2:13][C:14]([C:4]1[CH:3]=[CH:2][C:1]([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=1)=[O:15]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 70970Methanesulfonamide, N-phenyl-HCID 6451240Aluminum(III) Chloride

생성물 1

HCID 116629Methanesulfonamide, N-[4-(2-chloroacetyl)phenyl]-

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
-10 °C

실험 절차

In a flask containing 128.4 g (0.75 mole) of N-phenylmethanesulfonamide, 169.5 g (1.50 mole) of chloroacetyl chloride in 1 L of methylene chloride under an atmosphere of nitrogen and cooled to about -10° C. add 300 g (2.25 mole) of aluminum chloride. Stir the resulting mixture for about 2 hours at -10° C. then warm to room temperature for about 16 hours. Pour the reaction mixture onto 2 Kg of ice containing 600 mL of concentrated hydrochloric acid. Collect the precipitate and wash with methanol (3×300 mL) and dry in vacuo to give the title compound.

후처리

  1. temperaturethen warm to room temperature for about 16 hours
  2. customCollect the precipitate
  3. washwash with methanol (3×300 mL)
  4. customdry in vacuo

출처 및 근거

ORD 기록
ord-b24a3c0eee3e49658076d6d493e15730
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04613609

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