Methyl iodide → HCID 178480903, 화합물

HRID 65252

반응식

HRID 65252 반응식
[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1.[I:20][CH3:21]>CO>[I-:20].[OH:1][CH:2]([C:9]1[CH:10]=[CH:11][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:13][CH:14]=1)[CH2:3][N+:4]1[CH:8]=[CH:7][N:6]([CH3:21])[CH:5]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 13763390N-[4-(1-Hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide

생성물 1

HCID 178480903HCID 178480903, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Heat a solution of 4.0 g (14.2 mmole) of (±)-N-[4-[1-hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide, 2 ml (32.1 mmole) of iodomethane and 50 ml methanol in a glass pressure tube to 80° C. for 24 hours. Remove the solvent in vacuo. Crystallize the residue from acetone. Recrystallize from acetone to provide the title compound.

후처리

  1. customRemove the solvent in vacuo
  2. customCrystallize the residue from acetone
  3. customRecrystallize from acetone

출처 및 근거

ORD 기록
ord-30a8001166504f31b5d5e17ea568ca6b
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04613609

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