4-Chloro-2-nitroaniline → N-(4-chloro-2-nitrophenyl)acetamide
반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([N+:16]([O-:18])=[O:17])[CH:10]=1>S(=O)(=O)(O)O.O>[C:5]([NH:13][C:12]1[CH:14]=[CH:15][C:9]([Cl:8])=[CH:10][C:11]=1[N+:16]([O-:18])=[O:17])(=[O:7])[CH3:6]참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
To a mixture of 50 ml of acetic anhydride and two drops of sulfuric acid was added 34.5 grams of 4-chloro-2-nitroaniline in several portions. At the end of addition, the solution was heated at 50° C. for one hour and then allowed to cool. 300 ml of cold water was added to the solution to induce precipitation of crystals, which were removed by filtration and washed with water. There were obtained the crystals of 2-acetylamino-5-chloronitrobenzene in a yield of 41.8 grams.
후처리
- additionAt the end of addition
- temperatureto cool
- customprecipitation of crystals, which
- customwere removed by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-4dec328e5bcd40e98eb823388ebab255
- 출처 데이터셋
- uspto-grants-1987_06
- 특허 번호
- US04675277
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