Hydrochloric Acid → HCID 178425692, 화합물

HRID 653189

반응식

HRID 653189 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][N:3]=1.[NH:10]1[CH:17]=[CH:16][C:14](=[O:15])[NH:13][C:11]1=[S:12].Cl.C(=O)(O)[O-].[Na+]>CO>[OH:15][C:14]1[C:16]([CH:8]([C:5]2[CH:4]=[N:3][C:2]([CH3:1])=[CH:7][CH:6]=2)[OH:9])=[CH:17][N:10]=[C:11]([SH:12])[N:13]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 1269845ThiouracilHCID 101925666-Methyl-3-pyridinecarboxaldehyde

생성물 1

HCID 178425692HCID 178425692, 화합물수율 45.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 5 g (0.04 mol) of 2-methyl-5-formylpyridine, 5.29 g (0.04 mol) of 2-thiouracil and 50 ml of concentrated hydrochloric acid was heated overnight. The solution was neutralized with sodium bicarbonate. The organic material in the resulting precipitate was taken up in methanol which was then evaporated to give 4.53 g (45%) of 4-hydroxy-2-mercapto-5-[(6-methyl-3-pyridinyl)hydroxymethyl]pyrimidine [MS(m/e)250]. This compound (2 g) is treated with zinc-acetic acid as in Example 9 to give the same end product.

후처리

  1. temperaturewas heated overnight
  2. customwas then evaporated

출처 및 근거

ORD 기록
ord-b281c33505d3421fa4ef78bb81481455
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04675406

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