Ethyl Acetate → L-Phenylalanine

HRID 65321

반응식

HRID 65321 반응식
C[O:2][C:3](=[O:13])[CH:4]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[NH2:5].C(OCC)(=O)C.[OH-].[Na+]>O>[NH2:5][C@H:4]([C:3]([OH:13])=[O:2])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 75737DL-Phenylalanine, methyl ester

생성물 1

HCID 6140L-Phenylalanine수율 98%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1.15 grams of D,L-phenylalanine methyl ester in 2.5 milliliters of water was added to 5.0 milliliters of ethyl acetate. The pH was adjusted to 6.5 with 2.5 milliliters of sodium hydroxide. Two milligrams of chymotrypsin was added and the reaction was stirred gently at room temperature. A white precipitate appeared after 1.5 hours. The precipitate was isolated after 2 hours yielding 0.22 grams with an optical rotation equivalent to 98% pure L-phenylalanine.

후처리

  1. additionTwo milligrams of chymotrypsin was added
  2. customThe precipitate was isolated after 2 hours

출처 및 근거

ORD 기록
ord-a1998eaeb8504d398dcc88c0ffe4372b
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04613691

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