Hydrochloric Acid → 1-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol

HRID 653688

반응식

HRID 653688 반응식
[CH:1]1([CH2:11][C:12](=O)[CH3:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][O:2]1.[NH2:15][CH:16]([CH3:26])[CH:17]([C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1)[OH:18].Cl>CO>[OH:25][C:22]1[CH:21]=[CH:20][C:19]([CH:17]([OH:18])[CH:16]([NH:15][CH:12]([CH3:13])[CH2:11][CH:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3][O:2]2)[CH3:26])=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 110994-(2-Amino-1-hydroxypropyl)phenolHCID 127770631-(Isochroman-1-yl)propan-2-one

생성물 1

HCID 198899601-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol수율 72%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

An oily product was obtained in the same manner as in Example 1, using (isochroman-1-yl)acetone and 2-amino-1-(4-hydroxyphenyl)-1-propanol [J. Med. Chem., 14, 148 (1971)]. The product was dissolved in anhydrous methanol, and concentrated hydrochloric acid was added thereto. The solvent was evaporated off to give a hydrochloride. The hydrochloride was then washed with ether to give Compound 24 as crystals in a yield of 72%.

후처리

  1. customAn oily product was obtained in the same manner as in Example 1
  2. customThe solvent was evaporated off

출처 및 근거

ORD 기록
ord-309b8a8a7400410bb9a257c4a7f3f5cf
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05128369

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