Hydrochloric Acid → 1-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol

반응식

[CH:1]1([CH2:11][C:12](=O)[CH3:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][O:2]1.[NH2:15][CH:16]([CH3:26])[CH:17]([C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1)[OH:18].Cl>CO>[OH:25][C:22]1[CH:21]=[CH:20][C:19]([CH:17]([OH:18])[CH:16]([NH:15][CH:12]([CH3:13])[CH2:11][CH:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3][O:2]2)[CH3:26])=[CH:24][CH:23]=1

참가 물질

실험 절차

An oily product was obtained in the same manner as in Example 1, using (isochroman-1-yl)acetone and 2-amino-1-(4-hydroxyphenyl)-1-propanol [J. Med. Chem., 14, 148 (1971)]. The product was dissolved in anhydrous methanol, and concentrated hydrochloric acid was added thereto. The solvent was evaporated off to give a hydrochloride. The hydrochloride was then washed with ether to give Compound 24 as crystals in a yield of 72%.