Benzyl Bromide → 1,3-Dibromo-5-fluoro-2-(phenylmethoxy)benzene

HRID 654030노트

반응식

HRID 654030 반응식
[Na].[Br:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[C:5]([Br:10])[C:4]=1[OH:11].[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[Br-].[Na+]>C(O)C>[CH2:12]([O:11][C:4]1[C:3]([Br:2])=[CH:8][C:7]([F:9])=[CH:6][C:5]=1[Br:10])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

6

반응물 4

HCID 7498Benzyl BromideHCID 676542,6-Dibromo-4-fluorophenolHCID 253881Sodium BromideHCID 5360545Sodium

생성물 1

HCID 150576451,3-Dibromo-5-fluoro-2-(phenylmethoxy)benzene

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.21 g (96 mmol) of sodium is dissolved in 66 ml of ethanol with exclusion of moisture. 21.6 g (80 mmol) of 2,6-dibromo-4-fluorophenol is added to this solution. A suspension results. 20.5 g (120 mmol) of benzyl bromide is added to the suspension. It is stirred for 30 minutes at room temperature and then is refluxed for 1 hour. A sample of the suspension then reacts neutrally to moist reaction paper. The precipitate of the sodium bromide is suctioned off, the filtrate is evaporated to dryness and the residue is crystallized from ethanol. 23.7 g (66 mmol)=82.5% of the theoretical yield is obtained as a crystallizate. Melting point 83° C.

후처리

  1. customA suspension results
  2. temperatureis refluxed for 1 hour
  3. customA sample of the suspension then reacts neutrally to moist reaction paper
  4. customthe filtrate is evaporated to dryness
  5. customthe residue is crystallized from ethanol
  6. custom23.7 g (66 mmol)=82.5% of the theoretical yield
  7. customis obtained as a crystallizate

출처 및 근거

ORD 기록
ord-53d07509cf9d4c8aa2f910f1577888d5
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05130119

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