Hydrochloric Acid → 3-Phenoxypropane-1-thiol
반응식
[C:1]1([O:7][CH2:8][CH2:9][CH2:10]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.NC(N)=[S:14].[OH-].[K+].Cl>C(O)C.CO>[O:7]([CH2:8][CH2:9][CH2:10][SH:14])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
7
반응 조건
- 온도
- 50 °C
실험 절차
160 g of 3-bromopropyl phenyl ether and 63 g of thiourea were dissolved in 300 ml of ethanol and the solution was refluxed with heating for 3 hours. A methanol solution containing 194 g of potassium hydroxide was added to the reaction solution and the mixture was stirred at 50° C. for 2 hours. The mixture was poured into diluted hydrochloric acid and extracted with ethyl acetate followed by distillation under reduced pressure to obtain 76.5 g of 3-phenoxypropanethiol. A boiling point was 135° to 138° C. at 17 mm Hg.
후처리
- temperaturethe solution was refluxed
- temperaturewith heating for 3 hours
- additionwas added to the reaction solution
- extractionextracted with ethyl acetate
- distillationfollowed by distillation under reduced pressure
출처 및 근거
- ORD 기록
- ord-4750c884274143519e7a5c5c64cfe428
- 출처 데이터셋
- uspto-grants-1986_09
- 특허 번호
- US04614702
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