Phosphoric Acid → 3-(Benzyloxy)-1,2-propanediol

HRID 656315

반응식

HRID 656315 반응식
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:14][O:13]C(C)(C)[O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(=O)(O)(O)O.[OH-].[Na+].C([O-])([O-])=O.[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Al+3]>O.C(O)C>[CH2:1]([O:8][CH2:9][CH:10]([OH:11])[CH2:14][OH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 1004Phosphoric AcidHCID 14798Sodium HydroxideHCID 857952,2-Dimethyl-4-((phenylmethoxy)methyl)-1,3-dioxolaneHCID 2483886611097-59-9

생성물 1

HCID 980723-(Benzyloxy)-1,2-propanediol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

Into a 1 L beaker were weighed 222 g (1.0 mol) of 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane prepared in 1-2, 250 ml of ethanol, and 400 ml of distilled water, and the whole was adjusted to pH 2 with phosphoric acid. With introducing nitrogen thereinto, the solution was heated to 70° C. After 1.5 hours of the reaction, the solution was adjusted to pH 7.0 with sodium hydroxide. The resulting salt was subjected to adsorption treatment with an adsorbent “KYOWAAD 1000” (manufactured by Kyowa Hakko Kogyo Co., Ltd.) and then subjected to solvent removal to obtain 3-benzyloxy-1,2-propanediol.

후처리

  1. customAfter 1.5 hours of the reaction
  2. customsubjected to solvent removal

출처 및 근거

ORD 기록
ord-df30cbdd00a54e0bb1676e48eb262a3f
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071712B2

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